The Clathrin, Heavy Chain Antibody from MyBioSource.com is a Human, and Rabbit Polyclonal antibody to CHC, CHC17, clathrin, CLTC, and Miscellaneous. This antibody recognizes Human, Mouse, Rat, Bovine, and Non-Human Primate antigen. The Clathrin, Heavy Chain Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Clathrin-coated pits, intracellular transport vesicles involved in endocytosis and other membrane trafficking processes, are multi-component units. (1,2). Clathrin, the most abundant protein in these vesicles, is formed of a basic assembly unit called a triskelion composed of three clathrin heavy chains and three clathrin light chains. Together with other coat components such as AP2, epsin and EPS15, triskelia are targeted to appropriate membrane fusion sites, where subsequent invagination, cargo protein uptake and vesicle internalization occurs (3,4)